Osteoclasts, no longer osteoblast slaves

被引:18
作者
Boyce, Brendan F.
Xing, Lianping
机构
[1] Univ Rochester, Med Ctr, Dept Pathol & Lab Med, Rochester, NY 14642 USA
[2] Univ Rochester, Med Ctr, Ctr Musculoskeletal Res, Rochester, NY 14642 USA
关键词
D O I
10.1038/nm1206-1356
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A protein has been identified that promotes the formation of osteoclasts, bone-degrading cells-while also inhibiting osteoblasts, bone-forming cells. The findings could lead to new avenues of drug development to strengthen bone ( pages 1403-1409).
引用
收藏
页码:1356 / 1358
页数:4
相关论文
共 12 条
[1]   Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease [J].
Boyce, Brendan F. ;
Schwarz, Edward M. ;
Xing, Lianping .
CURRENT OPINION IN RHEUMATOLOGY, 2006, 18 (04) :427-432
[2]   PARATHYROID-HORMONE STIMULATES BONE-FORMATION AND RESORPTION IN ORGAN-CULTURE - EVIDENCE FOR A COUPLING MECHANISM [J].
HOWARD, GA ;
BOTTEMILLER, BL ;
TURNER, RT ;
RADER, JI ;
BAYLINK, DJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (05) :3204-3208
[3]   Parathyroid hormone plus alendronate - A combination that does not add up [J].
Khosla, S .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (13) :1277-1279
[4]   v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation [J].
Lee, Seoung-Hoon ;
Rho, Jaerang ;
Jeong, Daewon ;
Sul, Jai-Yoon ;
Kim, Taesoo ;
Kim, Nacksung ;
Kang, Ju-Seob ;
Miyamoto, Takeshi ;
Suda, Toshio ;
Lee, Sun-Kyeong ;
Pignolo, Robert J. ;
Koczon-Jaremko, Boguslawa ;
Lorenzo, Joseph ;
Choi, Yongwon .
NATURE MEDICINE, 2006, 12 (12) :1403-1409
[5]   Mechanisms involved in skeletal anabolic therapies [J].
Martin, T. J. ;
Quinn, J. M. W. ;
Gillespie, M. T. ;
Ng, K. W. ;
Karsdal, M. A. ;
Sims, N. A. .
SKELETAL DEVELOPMENT AND REMODELING IN HEALTH, DISEASE, AND AGING, 2006, 1068 :458-470
[6]   Osteoclast-derived activity in the coupling of bone formation to resorption [J].
Martin, TJ ;
Sims, NA .
TRENDS IN MOLECULAR MEDICINE, 2005, 11 (02) :76-81
[7]   Bisphosphonates - From bench to bedside [J].
Russell, R. Graham G. .
SKELETAL DEVELOPMENT AND REMODELING IN HEALTH, DISEASE, AND AGING, 2006, 1068 :367-401
[8]   Diversity of mouse proton-translocating ATPase:: presence of multiple isoforms of the C, d and G subunits [J].
Sun-Wada, GH ;
Yoshimizu, T ;
Imai-Senga, Y ;
Wada, Y ;
Futai, M .
GENE, 2003, 302 (1-2) :147-+
[9]   Mechanistic insight into osteoclast differentiation in osteolmmunology [J].
Takayanagi, H .
JOURNAL OF MOLECULAR MEDICINE-JMM, 2005, 83 (03) :170-179
[10]   Bone resorption by osteoclasts [J].
Teitelbaum, SL .
SCIENCE, 2000, 289 (5484) :1504-1508