In Vitro Imaging and in Vivo Liver Targeting with Carbohydrate Capped Quantum Dots

被引:203
作者
Kikkeri, Raghavendra [1 ]
Lepenies, Bernd [1 ]
Adibekian, Alexander [1 ]
Laurino, Paola [1 ]
Seeberger, Peter H. [1 ]
机构
[1] ETH, Swiss Fed Inst Technol, Organ Chem Lab, CH-8093 Zurich, Switzerland
关键词
TUMOR VASCULATURE; SURFACE-PROTEINS; ENERGY-TRANSFER; CDSE; RECEPTOR; CELLS; MICE;
D O I
10.1021/ja807711w
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
PEGylated quantum dots (QDs) capped with D-mannose, D-galactose, and D-galactosamine have been synthesized. The stable, high quantum yield fluorescence of QDs was exploited to study specific carbohydrate-protein interactions in vitro and in vivo.
引用
收藏
页码:2110 / +
页数:4
相关论文
共 37 条
[1]   Sugar-quantum dot conjugates for a selective and sensitive detection of lectins [J].
Babu, Ponnusamy ;
Sinha, Sharmistha ;
Surolia, Avadhesha .
BIOCONJUGATE CHEMISTRY, 2007, 18 (01) :146-151
[2]   GALACTOSE AND N-ACETYLGALACTOSAMINE-SPECIFIC ENDOCYTOSIS OF GLYCOPEPTIDES BY ISOLATED RAT HEPATOCYTES [J].
BAENZIGER, JU ;
FIETE, D .
CELL, 1980, 22 (02) :611-620
[3]   The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit [J].
Braun, JR ;
Willnow, TE ;
Ishibashi, S ;
Ashwell, G ;
Herz, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (35) :21160-21166
[4]   Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects [J].
Cai, WB ;
Shin, DW ;
Chen, K ;
Gheysens, O ;
Cao, QZ ;
Wang, SX ;
Gambhir, SS ;
Chen, XY .
NANO LETTERS, 2006, 6 (04) :669-676
[5]   Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging [J].
Cai, Weibo ;
Chen, Xiaoyuan .
NATURE PROTOCOLS, 2008, 3 (01) :89-96
[6]   Quantum dot bioconjugates for ultrasensitive nonisotopic detection [J].
Chan, WCW ;
Nie, SM .
SCIENCE, 1998, 281 (5385) :2016-2018
[7]  
Chen YF, 2003, NANO LETT, V3, P581, DOI 10.1021/n1034086g
[8]   Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors [J].
Clapp, AR ;
Medintz, IL ;
Mauro, JM ;
Fisher, BR ;
Bawendi, MG ;
Mattoussi, H .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (01) :301-310
[9]   Quantum dot-based multiplexed fluorescence resonance energy transfer [J].
Clapp, AR ;
Medintz, IL ;
Uyeda, HT ;
Fisher, BR ;
Goldman, ER ;
Bawendi, MG ;
Mattoussi, H .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (51) :18212-18221
[10]   Glyconanoparticles:: Types, synthesis and applications in glycoscience, biomedicine and material science [J].
De la Fuente, JM ;
Penadés, S .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, 1760 (04) :636-651