Effect of Danggui Buxue Tang on immune-mediated aplastic anemia bone marrow proliferation mice

被引：60

作者：

Yang, Xian ^{[1
,2
]}

Huang, Chong-Gang ^{[3
]}

Du, Shou-Ying ^{[1
]}

Yang, Shui-Ping ^{[4
]}

Zhang, Xue ^{[3
]}

Liu, Jian-Yi ^{[3
]}

Luo, Xian-Qin ^{[3
]}

Xu, Jia-Hong ^{[3
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China

[2] Chongqing Normal Univ, Coll Life Sci, Chongqing 401331, Peoples R China

[3] Chongqing Acad Chinese Mat Medico, Chongqing 400065, Peoples R China

[4] Southwest Univ, Coll Resources & Environm, Chongqing 400716, Peoples R China

来源：

PHYTOMEDICINE | 2014年 / 21卷 / 05期

关键词：

TCM Formula; Danggui Buxue Tang; Immune-mediated; Aplastic anemia mice; Bone marrow colony cell; RADIX ANGELICAE SINENSIS; HERBAL DECOCTION; ASTRAGALI;

D O I：

10.1016/j.phymed.2013.10.018

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

To investigate the pharmacological effects of Danggui Buxue Tang (DBT) on immune-mediated aplasia anemia mice. The model of immune-mediated aplasia anemia mice was induced by means of Co-60 gamma-ray irradiation and mixed cells of thymus and lymphnode of DBA/2 mice infusion through tail vein, the parameters tested indices were as following: blood picture, bone marrow nucleated cell count (BMNC), murine colony-forming unit-megakaryocytes (CFU-GM) of bone marrow cells, murine colony-forming unit-erthroid (CFU-E) and burst forming unit-erythroid (BFU-E). The results showed that DBT could not only withstand significantly decreation of blood cells by immune-mediated, but also stimulate on the growth of bone marrow colony cell and increase the weight of hemopoietic progenitor of bone marrow. Therefore, DBT had an obvious treat effect on immune-mediated aplasia anemia models mice. (c) 2013 Elsevier GmbH. All rights reserved.

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页码：640 / 646

页数：7

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