Severe Influenza-associated Respiratory Infection in High HIV Prevalence Setting, South Africa, 2009-2011

被引：127

作者：

Cohen, Cheryl ^{[1
,2
]}

Moyes, Jocelyn ^{[1
,2
]}

Tempia, Stefano ^{[3
,4
]}

Groom, Michelle ^{[2
]}

Walaza, Sibongile ^{[1
]}

Pretorius, Marthi ^{[1
]}

Dawood, Halima ^{[5
,6
]}

Chhagan, Meera ^{[5
]}

Haffejee, Summaya ^{[5
]}

Variava, Ebrahim ^{[2
,7
]}

Kahn, Kathleen ^{[2
,8
,9
]}

Tshangela, Akhona ^{[1
]}

von Gottberg, Anne ^{[1
,2
]}

Wolter, Nicole ^{[1
,2
]}

Cohen, Adam L. ^{[3
,4
]}

Kgokong, Babatyi ^{[1
]}

Venter, Marietjie ^{[1
,10
]}

Madhi, Shabir A. ^{[1
,2
]}

机构：

[1] Natl Hlth Lab Serv, Johannesburg, South Africa

[2] Univ Witwatersrand, Johannesburg, South Africa

[3] Ctr Dis Control & Prevent, Atlanta, GA USA

[4] Ctr Dis Control & Prevent South Africa, Pretoria, South Africa

[5] Univ KwaZulu Natal, Durban, South Africa

[6] Pietermaritzburg Metropolitan Hosp, Pietermaritzburg, South Africa

[7] Klerksdorp Tshepong Hosp, Klerksdorp, South Africa

[8] Umea Univ, Umea, Sweden

[9] INDEPTH Network, Accra, Ghana

[10] Univ Pretoria, ZA-0002 Pretoria, South Africa

来源：

EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 11期

关键词：

STREPTOCOCCUS-PNEUMONIAE; TRACT INFECTIONS; UNITED-STATES; DOUBLE-BLIND; CHILDREN; ADULTS; TIME; EFFICACY; VACCINE; BURDEN;

D O I：

10.3201/eid1911.130546

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Data on influenza epidemiology in HIV-infected persons are limited, particularly for sub-Saharan Africa, where HIV infection is widespread. We tested respiratory and blood samples from patients with acute lower respiratory tract infections hospitalized in South Africa during 2009-2011 for viral and pneumococcal infections. Influenza was identified in 9% (1,056/11,925) of patients enrolled; among influenza case-patients, 358 (44%) of the 819 who were tested were infected with HIV. Influenza-associated acute lower respiratory tract infection incidence was 4-8 times greater for HIV-infected (186-228/100,000) than for HIV-uninfected persons (26-54/100,000). Furthermore, multivariable analysis showed HIV-infected patients were more likely to have pneumococcal co-infection; to be infected with influenza type B compared with type A; to be hospitalized for 2-7 days or >7 days; and to die from their illness. These findings indicate that HIV-infected persons are at greater risk for severe illnesses related to influenza and thus should be prioritized for influenza vaccination.

引用

页码：1766 / 1774

页数：9

共 39 条

[1]

Actuarial Society of South Africa, AIDS DEM MOD

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