Structure and function of cardiac pacemaker channels

被引：71

作者：

Ludwig, A ^{[1
]}

Zong, XG ^{[1
]}

Hofmann, F ^{[1
]}

Biel, M ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Pharmakol & Toxikol, D-80802 Munich, Germany

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 1999年 / 9卷 / 4-5期

关键词：

hyperpolarization-activated current; pacemaker current; HCN channel;

D O I：

10.1159/000016315

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiac pacemaking is controlled by a mixed Na+/K+ current named I(f)i, which is activated by hyperpolarized membrane potentials. Recently, a family of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels has been cloned. The members of this family exhibit the general features of Ir channels. This review describes the molecular diversity of the HCN channel family and the structural determinants of channel function including activation by voltage, modulation by cylic nucleotides and ion permeation. The relationships between cloned HCN channel types and native cardiac If currents are explored. Copyright (C) 1999 S. Karger AG, Basel.

引用

页码：179 / 186

页数：8

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