T cell defined tumor antigens

被引：514

作者：

VandenEynde, BJ

vanderBruggen, P

机构：

[1] Ludwig Institute for Cancer Research, 74 Ave. Hippocrate, UCL 74.59, B., Brussels

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(97)80050-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell defined antigens have now been characterized in a large variety of tumor types, in both mice and humans. An increasing number of these antigens appear to result from tumor-specific mutations, and some of these mutations may be implicated in oncogenesis. The priority is now to demonstrate that immunization against some of these antigens is clinically valuable for antitumor therapy, and the first results of clinical pilot studies are now emerging.

引用

收藏

页码：684 / 693

页数：10

相关论文

共 115 条

[1] HLA ANTIGENS IN OCULAR-TISSUES .1. INVIVO EXPRESSION IN HUMAN EYES [J].

ABIHANNA, D ;

WAKEFIELD, D ;

WATKINS, S .

TRANSPLANTATION, 1988, 45 (03) :610-613

[2] Identification of overlapping epitopes in mutant ras oncogene peptides that activate CD4(+) and CD8(+)T cell responses [J].

Abrams, SI ;

Stanziale, SF ;

Lunin, SD ;

Zaremba, S ;

Schlom, J .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (02) :435-443

[3] PEPTIDE-SPECIFIC ACTIVATION OF CYTOLYTIC CD4(+) T-LYMPHOCYTES AGAINST TUMOR-CELLS BEARING MUTATED EPITOPES OF K-RAS P21 [J].

ABRAMS, SI ;

DOBRZANSKI, MJ ;

WELLS, DT ;

STANZIALE, SE ;

ZAREMBA, S ;

MASUELLE, L ;

KANTOR, JA ;

SCHLOM, J .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (09) :2588-2597

[4] MELANOMA-CELLS AND NORMAL MELANOCYTES SHARE ANTIGENS RECOGNIZED BY HLA-A2-RESTRICTED CYTOTOXIC T-CELL CLONES FROM MELANOMA PATIENTS [J].

ANICHINI, A ;

MACCALLI, C ;

MORTARINI, R ;

SALVI, S ;

MAZZOCCHI, A ;

SQUARCINA, P ;

HERLYN, M ;

PARMIANI, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (04) :989-998

[5]

BAKKER ABH, 1995, INT J CANCER, V62, P97

[6] Making the most of mucin: A novel target for tumor immunotherapy [J].

BarrattBoyes, SM .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 1996, 43 (03) :142-151

[7] Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma [J].

Bloom, MB ;

PerryLalley, D ;

Robbins, PF ;

Li, Y ;

ElGamil, M ;

Rosenberg, SA ;

Yang, JC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (03) :453-459

[8] BAGE - A NEW GENE ENCODING AN ANTIGEN RECOGNIZED ON HUMAN MELANOMAS BY CYTOLYTIC T-LYMPHOCYTES [J].

BOEL, P ;

WILDMANN, C ;

SENSI, ML ;

BRASSEUR, R ;

RENAULD, JC ;

COULIE, P ;

BOON, T ;

VANDERBRUGGEN, P .

IMMUNITY, 1995, 2 (02) :167-175

[9] Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death [J].

Boldin, MP ;

Goncharov, TM ;

Goltsev, YV ;

Wallach, D .

CELL, 1996, 85 (06) :803-815

[10] A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer [J].

Borysiewicz, LK ;

Fiander, A ;

Nimako, M ;

Man, S ;

Wilkinson, GWG ;

Westmoreland, D ;

Evans, AS ;

Adams, M ;

Stacey, SN ;

Boursnell, MEG ;

Rutherford, E ;

Hickling, JK ;

Inglis, SC .

LANCET, 1996, 347 (9014) :1523-1527

← 1 2 3 4 5 6 7 8 9 10 →