Direct L-proline-catalyzed asymmetric α-amination of ketones

被引：318

作者：

Kumaragurubaran, N ^{[1
]}

Juhl, K ^{[1
]}

Zhuang, W ^{[1
]}

Bogevig, A ^{[1
]}

Jorgensen, KA ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Ctr Catalysis, DK-8000 Aarhus C, Denmark

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 22期

关键词：

D O I：

10.1021/ja026412k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first direct catalytic asymmetric α-amination of ketones catalyzed by l-proline has been developed. The reactions proceed with various azodicarboxylates as the nitrogen source in high yields and excellent enantioselectivities (up to 99% ee). The scope and potential of the reaction are demonstrated by further transformation of the α-hydrazino ketones formed to both optically active syn and anti-α-amino alcohol derivatives. Copyright © 2002 American Chemical Society.

引用

页码：6254 / 6255

页数：2

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