P38 mitogen-activated protein kinase (MAPK) in rheumatoid arthritis

被引：62

作者：

Westra, J. ^{[1
]}

Limburg, P. C. ^{[1
]}

机构：

[1] Univ Groningen, Med Ctr, Dept Rheumatol, NL-9700 RB Groningen, Netherlands

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 08期

关键词：

rheumatoid arthritis; drug; p38; MAPK;

D O I：

10.2174/138955706777934982

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The importance of p38 MAPK inhibitors as new drug for rheumatoid arthritis is reflected by the large number of compounds that has been developed over the last years. In this review new insights such as non-stressful activation of p38 MAPK, and the role of p38 MAPK in regulation of NF-kappa B recruitment are also discussed.

引用

页码：867 / 874

页数：8

共 73 条

[1] Pyrimidinylimidazole inhibitors of CSBP/P37 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes [J].

Adams, JL ;

Boehm, JC ;

Kassis, S ;

Gorycki, PD ;

Webb, EF ;

Hall, R ;

Sorenson, M ;

Lee, JC ;

Ayrton, A ;

Griswold, DE ;

Gallagher, TF .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (22) :3111-3116

[2]

Badger AM, 1996, J PHARMACOL EXP THER, V279, P1453

[3] A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis [J].

Bathon, JM ;

Martin, RW ;

Fleischmann, RM ;

Tesser, JR ;

Schiff, MH ;

Keystone, EC ;

Genovese, MC ;

Wasko, MC ;

Moreland, LW ;

Weaver, AL ;

Markenson, J ;

Finck, BK .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (22) :1586-1593

[4] CELL CONTACT BETWEEN T-CELLS AND SYNOVIAL FIBROBLASTS CAUSES INDUCTION OF ADHESION MOLECULES AND CYTOKINES [J].

BOMBARA, MP ;

WEBB, DL ;

CONRAD, P ;

MARLOR, CW ;

SARR, T ;

RANGES, GE ;

AUNE, TM ;

GREVE, JM ;

BLUE, ML .

JOURNAL OF LEUKOCYTE BIOLOGY, 1993, 54 (05) :399-406

[5] Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia [J].

Branger, J ;

van den Blink, B ;

Weijer, S ;

Madwed, J ;

Bos, CL ;

Gupta, A ;

Yong, CL ;

Polmar, SH ;

Olszyna, DP ;

Hack, CE ;

van Deventer, SJH ;

Peppelenbosch, MP ;

van der Poll, T .

JOURNAL OF IMMUNOLOGY, 2002, 168 (08) :4070-4077

[6] Regulation of tumour necrosis factor α mRNA stability by the mitogen-activated protein kinase p38 signalling cascade [J].

Brook, M ;

Sully, G ;

Clark, AR ;

Saklatvala, J .

FEBS LETTERS, 2000, 483 (01) :57-61

[7] IDENTIFICATION OF A COMMON NUCLEOTIDE-SEQUENCE IN THE 3'-UNTRANSLATED REGION OF MESSENGER-RNA MOLECULES SPECIFYING INFLAMMATORY MEDIATORS [J].

CAPUT, D ;

BEUTLER, B ;

HARTOG, K ;

THAYER, R ;

BROWNSHIMER, S ;

CERAMI, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (06) :1670-1674

[8] Mechanisms of disease: Cytokine pathways and joint inflammation in rheumatoid arthritis. [J].

Choy, EHS ;

Panayi, GS .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (12) :907-916

[9] COLLAGENASE PRODUCTION BY RHEUMATOID SYNOVIAL CELLS - STIMULATION BY A HUMAN LYMPHOCYTE FACTOR [J].

DAYER, JM ;

RUSSELL, RGG ;

KRANE, SM .

SCIENCE, 1977, 195 (4274) :181-183

[10] Design of potent and selective 2-aminobenzimidazole-based p38α MAP kinase inhibitors with excellent in vivo efficacy [J].

de Dios, A ;

Shih, C ;

de Uralde, BL ;

Sánchez, C ;

Del Prado, M ;

Cabrejas, LMM ;

Pleite, S ;

Blanco-Urgoiti, J ;

Lorite, MJ ;

Nevill, CR ;

Bonjouklian, R ;

York, J ;

Vieth, M ;

Wang, Y ;

Magnus, N ;

Campbell, RM ;

Anderson, BD ;

McCann, DJ ;

Giera, DD ;

Lee, PA ;

Schultz, RM ;

Li, LC ;

Johnson, LM ;

Wolos, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (07) :2270-2273

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