Increased brain P-glycoprotein in morphine tolerant rats

被引：4

作者：

Aquilante, CL ^{[1
]}

Letrent, SP ^{[1
]}

Pollack, GM ^{[1
]}

Brouwer, KLR ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Div Drug Delivery & Disposit, Chapel Hill, NC 27599 USA

来源：

LIFE SCIENCES | 1999年 / 66卷 / 04期

关键词：

morphine; P-glycoprotein; morphine tolerance;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The objective of this study was to determine whether chronic morphine exposure increased P-glycoprotein in rat brain. Male Sprague-Dawley rats were treated with morphine, saline, or dexamethasone for 5 days. On day 6, antinociceptive effect was measured to evaluate the extent of functional tolerance to morphine. Brain P-glycoprotein was detected by Western blot analysis of whole brain homogenate. Morphine- and dexamethasone-treated rats exhibited decreased antinociceptive response when compared to saline-treated controls. Brain P-glycoprotein was approximately 2-fold higher in morphine-treated rats compared to saline controls based on Western blot analysis. Chronic morphine exposure appears to increase P-glycoprotein in rat brain. P-glycoprotein induction may enhance morphine efflux from the brain, thus reducing morphine's pharmacologic activity. Induction of P-glycoprotein may be one mechanism involved in the development of morphine tolerance. (C) 1999 Elsevier Science Inc.

引用

页码：PL47 / PL51

页数：5

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