Insights into obesity and insulin resistance from the study of extreme human phenotypes

被引：19

作者：

O'Rahilly, S

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England

[2] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QQ, England

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2002年 / 147卷 / 04期

关键词：

D O I：

10.1530/eje.0.1470435

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The detailed study of rare, extreme human phenotypes has a long and distinguished history in endocrinology. Such individuals have often acted as 'experiments of nature' providing important novel information regarding endocrine physiology and mechanistic insights relevant to the study of more common endocrine disorders. This review presents a personal experience of the study of two such extreme phenotypes, obesity and severe insulin resistance.

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页码：435 / 441

页数：7

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