Discovery and biological evaluation of a new family of potent modulators of multidrug resistance:: Reversal of multidrug resistance of mouse lymphoma cells by new natural jatrophane diterpenoids isolated from Euphorbia species

被引：112

作者：

Hohmann, J ^{[1
]}

Molnár, J

Rédei, D

Evanics, F

Forgo, P

Kálmán, A

Argay, G

Szabó, P

机构：

[1] Univ Szeged, Dept Pharmacognosy, H-6720 Szeged, Hungary

[2] Univ Szeged, Dept Med Microbiol, H-6720 Szeged, Hungary

[3] Univ Szeged, Dept Pharmaceut Anal, H-6720 Szeged, Hungary

[4] Univ Szeged, Dept Organ Chem, H-6720 Szeged, Hungary

[5] Hungarian Acad Sci, Inst Chem, Chem Res Ctr, H-1525 Budapest, Hungary

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 45卷 / 12期

关键词：

D O I：

10.1021/jm0111301

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The effects of 15 jatrophane diterpene polyesters (1-3 and 5-16) isolated from lipophilic extracts of Euphorbia serrulata, E. esula, E. salicifolia, and E. peplus (Euphorbiaceae) on the reversion of multidrug resistance of mouse lymphoma cells were examined. The structures of five new compounds (1-5) were elucidated by spectroscopic methods, including HRFABMS, ESIMS, H-1-H-1 homonuclear and H-1-C-13 heteronuclear correlations, long-range correlation spectra, and NOESY experiments. The stereochemistry and absolute configuration of one compound (3) were determined by X-ray crystallography. The structure-activity relationship is discussed.

引用

页码：2425 / 2431

页数：7

共 18 条

[1]

Macrocyclic diterpenoids from Euphorbia semiperfoliata [J].