Apoptosis inducers in chronic lymphocytic leukemia

被引：50

作者：

Billard, Christian ^{[1
,2
]}

机构：

[1] Ctr Rech Cordeliers, INSERM, U872, Equipe 18, Paris, France

[2] Univ Paris 06, UMRS 872, Paris, France

来源：

ONCOTARGET | 2014年 / 5卷 / 02期

关键词：

CLL; impaired cell death program; apoptosis-targeted therapies; apoptosis inducers; Bcl-2 family proteins; DEPENDENT KINASE INHIBITOR; SELECTIVE SMALL-MOLECULE; BCL-2 FAMILY PROTEINS; PROTEASOME INHIBITOR; UP-REGULATION; HISTONE DEACETYLASE; CELL-DEATH; ANTITUMOR-ACTIVITY; MCL-1; EXPRESSION; DOWN-REGULATION;

D O I：

10.18632/oncotarget.1480

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Chronic lymphocytic leukemia (CLL) is characterized by a typical defect in apoptosis and is still an incurable disease. Numerous apoptosis inducers have been described. These synthetic compounds and natural products (mainly derived from plants) display antileukemic properties in vitro and in vivo and some have even been tested in the clinic in CLL. They act through several different mechanisms. Most of them involve proteins of the Bcl-2 family, which are the key regulators in triggering the mitochondrial pathway of caspase-dependent apoptosis. Thus, the Mcl-1/Noxa axis appeared as a target. Here I overview natural and synthetic apoptosis inducers and their mechanisms of action in CLL cells. Opportunities for developing novel, apoptosis-based therapeutics are presented.

引用

收藏

页码：309 / 325

页数：17

相关论文

共 120 条

[1]

TMS, a chemically modified herbal derivative of Resveratrol, induces cell death by targeting Bax [J].

Aiyar, Sarah E. ;

Park, Hoyong ;

Aldo, Paulomi B. ;

Mor, Gil ;

Gildea, John J. ;

Miller, Aaron L. ;

Thompson, E. Brad ;

Castle, J. David ;

Kim, Sanghee ;

Santen, Richard J. .

BREAST CANCER RESEARCH AND TREATMENT, 2010, 124 (01) :265-277

[2]

Multiple BH3 Mimetics Antagonize Antiapoptotic MCL1 Protein by Inducing the Endoplasmic Reticulum Stress Response and Up-regulating BH3-only Protein NOXA [J].

Albershardt, Tina C. ;

Salerni, Bethany L. ;

Soderquist, Ryan S. ;

Bates, Darcy J. P. ;

Pletnev, Alexandre A. ;

Kisselev, Alexei F. ;

Eastman, Alan .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (28) :24882-24895

[3]

Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an ∼700 kDa Apaf-1 containing apoptosome complex [J].

Almond, JB ;

Snowden, RT ;

Hunter, A ;

Dinsdale, D ;

Cain, K ;

Cohen, GM .

LEUKEMIA, 2001, 15 (09) :1388-1397

[4]

Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM [J].

Alonso, Roberto ;

Lopez-Guerra, Monica ;

Upshaw, Ramanda ;

Bantia, Shanta ;

Smal, Caroline ;

Bontemps, Francoise ;

Manz, Chantal ;

Mehrling, Thomas ;

Villamor, Neus ;

Campo, Elias ;

Montserrat, Emili ;

Colomer, Dolors .

BLOOD, 2009, 114 (08) :1563-1575

[5]

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein [J].

Aron, JL ;

Parthun, MR ;

Marcucci, G ;

Kitada, S ;

Mone, AP ;

Davis, ME ;

Shen, TS ;

Murphy, T ;

Wickham, J ;

Kanakry, C ;

Lucas, DM ;

Reed, JC ;

Grever, MR ;

Byrd, JC .

BLOOD, 2003, 102 (02) :652-658

[6]

Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab [J].

Awan, Farrukh T. ;

Kay, Neil E. ;

Davis, Melanie E. ;

Wu, Wenting ;

Geyer, Susan M. ;

Leung, Nelson ;

Jelinek, Diane F. ;

Tschumper, Renee C. ;

Secreto, Charla R. ;

Lin, Thomas S. ;

Grever, Michael R. ;

Shanafelt, Tait D. ;

Zent, Clive S. ;

Call, Timothy G. ;

Heerema, Nyla A. ;

Lozanski, Gerard ;

Byrd, John C. ;

Lucas, David M. .

BLOOD, 2009, 113 (03) :535-537

[7]

Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells [J].

Balakrishnan, Kumudha ;

Wierda, William G. ;

Keating, Michael J. ;

Gandhi, Varsha .

BLOOD, 2008, 112 (05) :1971-1980

[8]

Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells [J].

Balakrishnan, Kumudha ;

Aggarwal, Sumesh ;

Wierda, William ;

Gandhi, Varsha .

LEUKEMIA & LYMPHOMA, 2013, 54 (05) :1097-1100

[9]

Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia [J].

Balakrishnan, Kumudha ;

Verma, Dushyant ;

O'Brien, Susan ;

Kilpatrick, John Michael ;

Chen, Yuling ;

Tyler, Brenita F. ;

Bickel, Susan ;

Bantia, Shanta ;

Keating, Michael J. ;

Kantarjian, Hagop ;

Gandhi, Varsha ;

Ravandi, Farhad .

BLOOD, 2010, 116 (06) :886-892

[10]

AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance [J].

Balakrishnan, Kumudha ;

Burger, Jan A. ;

Wierda, William G. ;

Gandhi, Varsha .

BLOOD, 2009, 113 (01) :149-153

← 1 2 3 4 5 6 7 8 9 10 →