Implementation of a combined association-linkage model for quantitative traits in linear mixed model procedures of statistical packages

被引:6
作者
Beem, A. Leo [1 ]
Boomsma, Dorret I. [1 ]
机构
[1] Free Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands
关键词
D O I
10.1375/twin.9.3.325
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A transmission disequilibrium test for quantitative traits which combines association and linkage analyses is currently available in several dedicated software packages. We describe how to implement such models in linear mixed model procedures that are available in widely used statistical packages such as SPSS. We also briefly mention a few extensions of the model that become naturally available once the model is implemented in such procedures.
引用
收藏
页码:325 / 333
页数:9
相关论文
共 20 条
[1]   A general test of association for quantitative traits in nuclear families [J].
Abecasis, GR ;
Cardon, LR ;
Cookson, WOC .
AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 66 (01) :279-292
[2]   Merlin-rapid analysis of dense genetic maps using sparse gene flow trees [J].
Abecasis, GR ;
Cherny, SS ;
Cookson, WO ;
Cardon, LR .
NATURE GENETICS, 2002, 30 (01) :97-101
[3]   Detecting disease associations due to linkage disequilibrium using haplotype tags: A class of tests and the determinants of statistical power [J].
Chapman, JM ;
Cooper, JD ;
Todd, JA ;
Clayton, DG .
HUMAN HEREDITY, 2003, 56 (1-3) :18-31
[4]   Use of unphased multilocus genotype data in indirect association studies [J].
Clayton, D ;
Chapman, J ;
Cooper, J .
GENETIC EPIDEMIOLOGY, 2004, 27 (04) :415-428
[5]  
Falconer D.S., 1996, Quantitative Genetics, V4th
[6]  
Fitzmaurice GM., 2004, APPL LONGITUDINAL AN
[7]   Combined linkage and association sib-pair analysis for quantitative traits [J].
Fulker, DW ;
Cherny, SS ;
Sham, PC ;
Hewitt, JK .
AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (01) :259-267
[8]   Analysis of variance - Why it is more important than ever [J].
Gelman, A .
ANNALS OF STATISTICS, 2005, 33 (01) :1-31
[9]   MAXIMUM-LIKELIHOOD ESTIMATION FOR MIXED ANALYSIS OF VARIANCE MODEL [J].
HARTLEY, HO ;
RAO, JNK .
BIOMETRIKA, 1967, 54 :93-&
[10]  
Harville D.A., 1998, Matrix algebra from a statistician's perspective