Stereoselective synthesis of novel conformationally restricted β- and γ-amino acids

被引：62

作者：

Gnad, F ^{[1
]}

Poleschak, M ^{[1
]}

Reiser, O ^{[1
]}

机构：

[1] Univ Regensburg, Inst Organ Chem, D-93040 Regensburg, Germany

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 22期

关键词：

amino acids; cyclopropanes; peptidomimetics; catalysis; pyridines; indoles;

D O I：

10.1016/j.tetlet.2004.04.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel conformationally restricted beta- and gamma-amino acids containing a cyclopropane ring could be stereoselectively synthesized from readily available 5-methoxyindole and pyridine by copper(1)-catalyzed cyclopropanation with methyl diazoacetate followed by Subsequent oxidative cleavage of the resulting adducts. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4277 / 4280

页数：4

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