Tetrahydrogestrinone is a potent androgen and progestin

被引：60

作者：

Death, AK

McGrath, KCY

Kazlauskas, R

Handelsman, DJ ^{[1
]}

机构：

[1] ANZAC Res Inst, Sydney, NSW 2139, Australia

[2] Heart Res Inst, Sydney, NSW 2050, Australia

[3] Univ Sydney, Sydney, NSW 2006, Australia

[4] Australian Govt Analyt Labs, Australian Sports Drug Testing Lab, Pymble, NSW 2073, Australia

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2004年 / 89卷 / 05期

关键词：

D O I：

10.1210/jc.2004-0033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tetrahydrogestrinone (THG) was recently identified as a novel steroid used illicitly to improve athletic performance. Although its structure is closely related to gestrinone, a 19-nor progestin, and resembles that of trenbolone, THG was never marketed, so information on its hormonal properties is not known. In this study, we demonstrate that THG is a highly potent androgen and progestin in a yeast-based in vitro bioassay system expressing human androgen and progesterone receptors. It has no estrogenic activity and no antagonism for any of the three steroid receptor classes.

引用

页码：2498 / 2500

页数：3

共 20 条

[1]

[Anonymous], 2001, Endocrinology

[2] Detection of norbolethone, an anabolic steroid never marketed, in athletes' urine [J].