Effect of pyridone carboxylic acid anti-microbials on the generation of reactive oxygen species in vitro

被引：14

作者：

Akamatsu, H

Niwa, Y

Sasaki, H

Matoba, Y

Asada, Y

Horio, T

机构：

[1] Department of Dermatology, Kansai Medical University, Osaka

[2] Department of Dermatology, Kansai Medical University, Osaka 570, 10-15, Fumizono-cho, Moriguchi

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1996年 / 24卷 / 04期

关键词：

ofloxacin; ciprofloxacin; balofloxacin; neutrophil(s); reactive oxygen species;

D O I：

10.1177/030006059602400405

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of ofloxacin, ciprofloxacin and balofloxacin on the reactive oxygen species (ROS) levels generated by human neutrophils was examined in vitro; ROS generated in a cell-free, xanthine-xanthine oxidase system was also assessed. The species investigated were superoxide radical anion (O-2(-)), hydrogen peroxide (H2O2) and hydroxyl radical (OH .). Both ofloxacin and ciprofloxacin markedly decreased the levels of O-2(-), H2O2 and OH . generated by human neutrophils. On the other hand, these drugs did not affect any of the ROS examined in the xanthine-xanthine oxidase system. Balofloxacin showed no significant effect on ROS generated by either system. The present study indicates that ofloxacin and ciprofloxacin may exert an anti-inflammatory action by reducing the potent ROS species excessively generated by neutrophils at the sites of inflammation.

引用

页码：345 / 351

页数：7

共 12 条

[1]

AKAMATSU H, 1992, ACTA DERM-VENEREOL, V72, P178

[2] THE INHIBITION OF FREE-RADICAL GENERATION BY HUMAN NEUTROPHILS THROUGH THE SYNERGISTIC EFFECTS OF METRONIDAZOLE WITH PALMITOLEIC ACID - A POSSIBLE MECHANISM OF ACTION OF METRONIDAZOLE IN ROSACEA AND ACNE [J].