Cross-talk between bacterial pathogens and their host cells

被引：119

作者：

Galan, JE

Bliska, JB

机构：

[1] Dept. Molec. Genet. and Microbiol., State Univ. New York at Stony Brook, Stony Brook

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 1996年 / 12卷

关键词：

bacterial pathogenicity; signal transduction; protein secretion;

D O I：

10.1146/annurev.cellbio.12.1.221

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A taxonomically diverse group of bacterial pathogens have evolved a variety of strategies to subvert host-cellular functions to their advantage. This often involves two-way biochemical interactions leading to responses in both the pathogen and host cell. Central to this interaction is the function of a specialized protein secretion system that directs the export and/or translocation into the host cells of a number of bacterial proteins that can induce or interfere with host-cell signal transduction pathways. The understanding of these bacterial/host-cell interactions will not only lead to novel therapeutic approaches but will also result in a better understanding of a variety of basic aspects of cell physiology and immunology.

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收藏

页码：221 / 255

页数：35

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