The neuropsychological profile of psychotic major depression and its relation to cortisol

被引:106
作者
Gomez, Rowena G.
Fleming, Shelley H.
Keller, Jennifer
Flores, Benjamin
Kenna, Heather
DeBattista, Charles
Solvason, Brent
Schatzberg, Alan F.
机构
[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
[2] Palo Alto Vet Hlth Care Syst, Palo Alto, CA USA
关键词
affective disorders; psychotic major depression; cognition; neuropsychology; cortisol;
D O I
10.1016/j.biopsych.2005.11.010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Our study described the neuropsycbological profile of psychotic major depression (PMD) compared to nonpsycbotic major depression (NPMD) patients and psychiatrically healthy controls (HC). We predicted that higher cortisol levels would be associated with greater cognitive deficits. Methods. Twenty-nine PMDs, 24 NPMDs, and 26 HCs were recruited at Stanford University Medical Center. Psychiatric ratings, cortisol levels from 1800-0900 hours, and neuropsycbological test data were obtained. Results. PMDs bad more severe cognitive impairments compared with NPMDs and HCs with the exception of simple verbal attention. PMDs had elevated mean cortisol levels from 1800 to 0100 hours which were significantly correlated with poorer verbal memory and psychomotor speed performance. Cortisol slopes from 1800 to 0100 hours were also significantly correlated with verbal memory and working memory. Conclusions. Wbile PMD's ability to attendpassively to information appeal's intact, they have more difficulty processing, manipulating, and encoding new information. Elevated cortisol levels, as seen in PMD patients, are associated with poorer cognitive performance especially related to verbal memory for lists of words and working memory.
引用
收藏
页码:472 / 478
页数:7
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