Age-related changes in the regional variations in the number and subsets of intraepithelial lymphocytes in mouse small intestine

被引：11

作者：

Suzuki, H ^{[1
]}

Jeong, KI ^{[1
]}

Doi, K ^{[1
]}

机构：

[1] Univ Tokyo, Fac Agr, Dept Vet Pathol, Bunkyo Ku, Tokyo 1138657, Japan

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2002年 / 26卷 / 06期

关键词：

intraepithelial lymphocytes; lymphocyte subsets; age-related change; regional variation; small intestine; alpha beta T cells; gamma delta T cells; mice;

D O I：

10.1016/S0145-305X(02)00004-6

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 [水产];

摘要：

Previously, we reported regional variations in the number and subsets of the small intestinal IELs of mice. In this study. we examined the age-related changes in the regional variations of IELs in mice front 2 to I I weeks old. IELs were isolated from the proximal, middle and distal parts of the small intestine and analysed by flow cytometry. The total number of IELs gradually increased with age and reached a plateau at 8 weeks old, As to IEL subsets. the percentage of a 0 T cells was higher in the distal part at and after 2 weeks of age (before weaning). The percentage of the alphabeta T cell subset of extrathymic origin was higher in the proximal part while the percentages of alphabeta T cell subsets of thymic origin were higher in the distal part at and after 3 weeks (just after weaning). It appears that regional variations in IELs may be formed before the weaning period in mice. (C) 2002 Published by Elsevier Science Ltd.

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收藏

页码：589 / 595

页数：7

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