Health status in patients with chronic fatigue syndrome and in general population and disease comparison groups

被引:178
作者
Komaroff, AL
Fagioli, LR
Doolittle, TH
Gandek, B
Gleit, MA
Guerriero, RT
Kornish, J
Ware, NC
Ware, JE
Bates, DW
机构
[1] HARVARD UNIV, SCH MED, DEPT SOCIAL MED, BOSTON, MA 02115 USA
[2] TUFTS UNIV NEW ENGLAND MED CTR, INST HLTH, BOSTON, MA 02111 USA
关键词
D O I
10.1016/S0002-9343(96)00174-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
PURPOSE: TO measure the functional status and well-being of patients with chronic fatigue syndrome (CFS), and compare them with those of a general population group and six disease comparison groups. PATIENTS AND METHODS: The subjects of the study were patients with CFS (n = 223) from a CFS clinic, a population-based control sample (n = = 2,474), and disease comparison groups with hypertension (n = 2,089), congestive heart failure (n = 216), type II diabetes mellitus (n = 163), acute myocardial infarction (n = 107), multiple sclerosis (n = 25), and depression (n = 502). We measured functional status and wellbeing using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), which is a Self-administered questionnaire in which lower scores are indicative of greater impairment. RESULTS: Patients with CFS had far lower mean scores than the general population control subjects on all eight SF-36 scales. They also scored significantly lower than patients in all the disease comparison groups other than depression on virtually all the scales. When compared with patients with depression, they scored significantly lower on all the scales except for scales measuring mental health and role disability due to emotional problems, on which they scored significantly higher. The two SF-36 scales reflecting mental health were not correlated with any of the symptoms of CFS except for irritability and depression. CONCLUSION: Patients with CFS had marked impairment, in comparison with the general population and disease comparison groups. Moreover, the degree and pattern of impairment was different from that seen in patients with depression.
引用
收藏
页码:281 / 290
页数:10
相关论文
共 54 条
  • [1] ARMITAGE P, 1987, STAT METHODS MED RES, P70
  • [2] POSSIBLE UP-REGULATION OF HYPOTHALAMIC 5-HYDROXYTRYPTAMINE RECEPTORS IN PATIENTS WITH POSTVIRAL FATIGUE SYNDROME
    BAKHEIT, AMO
    BEHAN, PO
    DINAN, TG
    GRAY, CE
    OKEANE, V
    [J]. BRITISH MEDICAL JOURNAL, 1992, 304 (6833) : 1010 - 1012
  • [3] BARRETT JE, 1988, ARCH GEN PSYCHIAT, V45, P1100
  • [4] CLINICAL LABORATORY TEST FINDINGS IN PATIENTS WITH CHRONIC FATIGUE SYNDROME
    BATES, DW
    BUCHWALD, D
    LEE, J
    KITH, P
    DOOLITTLE, T
    RUTHERFORD, C
    CHURCHILL, WH
    SCHUR, PH
    WENER, M
    WYBENGA, D
    WINKELMAN, J
    KOMAROFF, AL
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (01) : 97 - 103
  • [5] PREVALENCE OF FATIGUE AND CHRONIC FATIGUE SYNDROME IN A PRIMARY-CARE PRACTICE
    BATES, DW
    SCHMITT, W
    BUCHWALD, D
    WARE, NC
    LEE, J
    THOYER, E
    KORNISH, RJ
    KOMAROFF, AL
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1993, 153 (24) : 2759 - 2765
  • [6] CHRONIC FATIGUE AND THE CHRONIC-FATIGUE-SYNDROME - PREVALENCE IN A PACIFIC-NORTHWEST HEALTH-CARE SYSTEM
    BUCHWALD, D
    UMALI, P
    UMALI, J
    KITH, P
    PEARLMAN, T
    KOMAROFF, AL
    [J]. ANNALS OF INTERNAL MEDICINE, 1995, 123 (02) : 81 - 88
  • [7] A CHRONIC ILLNESS CHARACTERIZED BY FATIGUE, NEUROLOGIC AND IMMUNOLOGICAL DISORDERS, AND ACTIVE HUMAN HERPESVIRUS TYPE-6 INFECTION
    BUCHWALD, D
    CHENEY, PR
    PETERSON, DL
    HENRY, B
    WORMSLEY, SB
    GEIGER, A
    ABLASHI, DV
    SALAHUDDIN, SZ
    SAXINGER, C
    BIDDLE, R
    KIKINIS, R
    JOLESZ, FA
    FOLKS, T
    BALACHANDRAN, N
    PETER, JB
    GALLO, RC
    KOMAROFF, AL
    [J]. ANNALS OF INTERNAL MEDICINE, 1992, 116 (02) : 103 - 113
  • [8] BUCHWALD D, 1996, AM J MED, V101
  • [9] CALIGIURI M, 1987, J IMMUNOL, V139, P3306
  • [10] ALTERED CYTOKINE RELEASE IN PERIPHERAL-BLOOD MONONUCLEAR CELL-CULTURES FROM PATIENTS WITH THE CHRONIC FATIGUE SYNDROME
    CHAO, CC
    JANOFF, EN
    HU, SX
    THOMAS, K
    GALLAGHER, M
    TSANG, M
    PETERSON, PK
    [J]. CYTOKINE, 1991, 3 (04) : 292 - 298