Absolute configuration of novel bioactive flavonoids from Tephrosia purpurea

被引:41
作者
Chang, LC
Chávez, D
Song, LL
Farnsworth, NR
Pezzuto, JM
Kinghorn, AD [1 ]
机构
[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA
关键词
D O I
10.1021/ol990407c
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] Three novel flavonoids, (+) tephrorins A (1) and B (2) and (+)-tephrosone (3), were isolated from Tephrosia purpurea, Their structures were elucidated by NMR spectral analysis, and their absolute configurations were determined by Mosher ester methodology. Compounds 1 and 2 are flavanones containing an unusual tetrahydrofuran moiety, Compounds 1-3 were evaluated for their potential cancer chemopreventive properties using a cell based quinone reductase induction assay.
引用
收藏
页码:515 / 518
页数:4
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