DNA damage-induced activation of ATM and ATM-dependent signaling pathways

被引：372

作者：

Kurz, EU ^{[1
]}

Lees-Miller, SP ^{[1
]}

机构：

[1] Univ Calgary, Canc Biol Res Grp, Dept Biochem & Mol Biol, Calgary, AB T2N 4N1, Canada

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

关键词：

ataxia-telangiectasia mutated; cell cycle checkpoint; DNA damage; DNA double-strand breaks; ionizing radiation; p53;

D O I：

10.1016/j.dnarep.2004.03.029

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizing radiation. Activation of ATM results in phosphorylation of many downstream targets that modulate numerous damage response pathways, most notably cell cycle checkpoints. In this review, we describe recent developments in our understanding of the mechanism of activation of ATM and its downstream signaling pathways. and explore whether DNA double-strand breaks are the sole activators of ATM and ATM-dependent signaling pathways. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：889 / 900

页数：12

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