Control of Nanoparticle Release Kinetics from 3D Printed Hydrogel Scaffolds

被引：37

作者：

Baumann, Bernhard ^{[1
]}

Jungst, Tomasz ^{[2
,3
]}

Stichler, Simone ^{[2
,3
]}

Feineis, Susanne ^{[2
,3
]}

Wiltschka, Oliver ^{[1
]}

Kuhlmann, Matthias ^{[2
,3
]}

Linden, Mika ^{[1
]}

Groll, Juergen ^{[2
,3
]}

机构：

[1] Univ Ulm, Inst Inorgan Chem 2, Albert Einstein Allee 11, D-89081 Ulm, Germany

[2] Univ Wurzburg, Dept Funct Mat Med & Dent, D-97070 Wurzburg, Germany

[3] Univ Wurzburg, BPI, D-97070 Wurzburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 16期

基金：

欧盟第七框架计划; 欧洲研究理事会;

关键词：

biofabrication; charge interaction; controlled release; gold nanoparticles; mesoporous silica nanoparticles; SILICA NANOPARTICLES; CANCER-CELLS; CONSTRUCTS; TISSUES;

D O I：

10.1002/anie.201700153

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The convergence of biofabrication with nanotechnology is largely unexplored but enables geometrical control of cell-biomaterial arrangement combined with controlled drug delivery and release. As a step towards integration of these two fields of research, this study demonstrates that modulation of electrostatic nanoparticle-polymer and nanoparticle-nanoparticle interactions can be used for tuning nanoparticle release kinetics from 3D printed hydrogel scaffolds. This generic strategy can be used for spatiotemporal control of the release kinetics of nanoparticulate drug vectors in biofabricated constructs.

引用

页码：4623 / 4628

页数：6

共 22 条

[1]

[Anonymous], 2015, ANGEW CHEM, V127, P2858

[2]

[Anonymous], 2013, ANGEW CHEM, V125, P1194

[3]

A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering [J].