Vaccination in the elderly: an immunological perspective

被引：146

作者：

Chen, Wilbur H. ^{[1
]}

Kozlovsky, Bernard F. ^{[2
]}

Effros, Rita B. ^{[3
]}

Grubeck-Loebenstein, Beatrix ^{[4
]}

Edelman, Robert ^{[1
]}

Sztein, Marcelo B. ^{[1
]}

机构：

[1] Univ Maryland, Ctr Vaccine Dev, Sch Med, Baltimore, MD 21201 USA

[2] Univ Maryland, Dept Epidemiol & Prevent Med, Sch Med, Baltimore, MD 21201 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[4] Austrian Acad Sci, Inst Biomed Aging Res, A-6020 Innsbruck, Austria

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 07期

基金：

奥地利科学基金会; 美国国家卫生研究院;

关键词：

HEPATITIS-B-VACCINE; HUMORAL IMMUNE-RESPONSE; T-CELL RESPONSES; INFLUENZA VACCINATION; REPLICATIVE SENESCENCE; ANTIBODY-RESPONSE; SURFACE-ANTIGEN; PNEUMOCOCCAL POLYSACCHARIDE; CYTOMEGALOVIRUS-INFECTION; CONJUGATE VACCINE;

D O I：

10.1016/j.it.2009.05.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Successful vaccination of the elderly against important infectious pathogens that cause high morbidity and mortality represents a growing public health priority. Building on the theme of aging and immunosenescence, we review mechanisms of human immunosenescence and the immune response to currently licensed vaccines. We discuss the difficulties in identifying the risk factors that, in addition to aging, cause immunosenescence and address the relative paucity of vaccine studies in the elderly. We conclude that vaccine responses are blunted in the elderly compared with that of healthy young adults. However, it is also clear that our understanding of the mechanisms underlying immunosenescence is limited and much remains to be learned to improve the effectiveness of next generation vaccines.

引用

页码：351 / 359

页数：9

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