Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis

被引：78

作者：

Miller, RG

Bryan, WW

Dietz, MA

Munsat, TL

Petajan, JH

Smith, SA

Goodpasture, JC

机构：

[1] CALIF PACIFIC MED CTR,DEPT NEUROL,SAN FRANCISCO,CA

[2] UNIV TEXAS,DEPT NEUROL,DALLAS,TX 75230

[3] ASSOCIATES NEUROL,BOULDER,CO

[4] TUFTS UNIV,NEW ENGLAND MED CTR,BOSTON,MA 02111

[5] UNIV UTAH,SALT LAKE CITY,UT 84112

[6] UNIV MINNESOTA,MINNEAPOLIS,MN 55455

[7] SYNTEX SYNERGEN NEUROSCI JOINT VENTURE,PALO ALTO,CA

来源：

NEUROLOGY | 1996年 / 47卷 / 05期

关键词：

D O I：

10.1212/WNL.47.5.1329

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined the toxicity of both single and multiple subcutaneous injections of recombinant human ciliary neurotrophic factor (rhCNTF) in 72 patients with ALS, in doses ranging from 2 to 100 mu g/kg. Adverse events were generally dose related and ranged from mild to severe. The tolerability of daily subcutaneous rhCNTF was equivalent to placebo at doses less than or equal to 5 mu g/kg/day. At higher doses, anorexia, weight loss, reactivation of herpes simplex virus (HSV1) labialis/stomatitis, cough, and increased oral secretions occurred.

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页码：1329 / 1331

页数：3

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