Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component

被引：25

作者：

Li, BA ^{[1
]}

Mackay, DR ^{[1
]}

Ma, J ^{[1
]}

Dai, X ^{[1
]}

机构：

[1] Univ Calif Irvine, Coll Med, Dept Biol Chem, Ctr Dev Biol, Irvine, CA 92697 USA

来源：

GENOMICS | 2004年 / 84卷 / 02期

关键词：

Wg/Wnt signaling; beta-catenin; LEF/TCF; pygopus; mpygo2; mpygo1; skin; hair follicles;

D O I：

10.1016/j.ygeno.2004.04.007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent studies in Drosophila identified pygopus, which encodes a PHD finger protein, as an additional nuclear component of the canonical Wingless (Wg)/Wnt signaling pathway. In this study, we describe the molecular cloning and expression analysis of a mouse pygopus gene, mpygo2. mpygo2 transcripts were detected in almost all adult mouse tissues examined, whereas transcripts of another mouse pygopus gene, mpygo1, were detected only in heart tissue. Abundant mpygo2 transcripts were observed during embryogenesis in multiple developmental sites. Consistent with the demonstrated role of the Wnt-beta-catenin-LEF/TCF signaling pathway in mammalian skin development, mpygo2 expression was detected in the developing epidermis and hair follicles, which suggests that mpygo2 might mediate the effect of this signaling pathway in mouse skin. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：398 / 405

页数：8

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