Absolute stereostructures of three new sesquiterpenes from the fruit of Alpinia oxyphylla with inhibitory effects on nitric oxide production and degranulation in RBL-2H3 cells

被引：104

作者：

Morikawa, T ^{[1
]}

Matsuda, H ^{[1
]}

Toguchida, I ^{[1
]}

Ueda, K ^{[1
]}

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 10期

关键词：

D O I：

10.1021/np020078o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The 80% aqueous acetone extract and the ethyl acetate-soluble portion from the dried fruit of Alpinia oxyphylla MIQUEL Were found to show inhibitory effects on nitric oxide production in lipopolysaccharide-activated activated macrophages and antigen-induced degranulation in RBL-2H3 cells. A new eudesmane-type sesquiterpene, oxyphyllol A, and two eremophilane-type sesquiterpenes, oxyphyllols B and C, were isolated from the ethyl acetate-soluble portion, together with 16 known constituents. The absolute stereostructures of oxyphyllols A, B, and C were determined on the basis of chemical and physicochemical evidence. The effects of isolated component on nitric oxide production were examined, and nine constituents including oxyphyllol A and nootkatone were found to show inhibitory activity. On the other hand, five constituents inhibited the release of beta-hexosaminidase from RBL-2H3 cells.

引用

页码：1468 / 1474

页数：7

共 32 条

[1] DEPROTONATION INDUCED C-13 NMR SHIFTS IN PHENOLS AND FLAVONOIDS [J].