The evolution of ribonucleotide reduction

被引:81
作者
Reichard, P
机构
关键词
D O I
10.1016/S0968-0004(97)01003-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ribonucleotide reduction was essential for the transition from RNA to DNA by supplying deoxyribonucleotide precursors. The reaction requires free radical chemistry. Three quite different classes of ribonucleotide reductases are known today. All three are proteins containing a stable free radical amino acid, but each uses a different mechanism for its generation. Did they evolve from a common ancestor, with the arrival of atmospheric oxygen providing the driving force for their divergence, or was each a separate evolutionary invention?.
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页码:81 / 85
页数:5
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