Homocysteine and carotid intima-media thickness in a German population -: Lack of clinical relevance

被引:44
作者
Linnebank, Michael
Moskau, Susanna
Farmand, Susan
Fliessbach, Klaus
Koelsch, Heike
Boes, Monika
Grothe, Christoph
Becker, Dietmar
Harbrecht, Ursula
Pohl, Christoph
Wuellner, Ullrich
Klockgether, Thomas
机构
[1] Univ Hosp Bonn, Dept Neurol, D-53105 Bonn, Germany
[2] Univ Hosp Bonn, Dept Epileptol, D-53105 Bonn, Germany
[3] Univ Hosp Bonn, Dept Psychiat, D-53105 Bonn, Germany
[4] Univ Hosp Bonn, Dept Transfus Med, D-53105 Bonn, Germany
关键词
carotid intima-media thickness; carotid ultrasound; genetics; homocysteinemia; stroke;
D O I
10.1161/01.STR.0000244764.02851.d3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose-Common carotid artery intima-media thickness (CCA IMT) is a predictor of stroke. This study aimed to analyze whether homocysteine (Hcys) metabolism influences CCA IMT. Methods-We analyzed the association of personal, clinical, and biochemical data (multivariate analysis) and of 9 polymorphisms involved in Hcys metabolism (ANOVA) with CCA IMT in 714 individuals of 187 families. Results-CCA IMT was significantly predicted by age, sex, creatinine levels, lipoprotein(a) levels, pack-years of smoking, the presence of hypertension, and the presence of diabetes mellitus but not by Hcys levels. Homozygosity for the T allele of the polymorphism methylenetetrahydrofolate reductase c.677C > T was significantly associated with higher Hcys levels but not with a higher CCA IMT. Conclusions-These data do not support the thesis that elevated Heys levels are causally involved in cerebrovascular disease.
引用
收藏
页码:2840 / 2842
页数:3
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