Nondeletional pathways for the development of autoreactive thymocytes

被引：16

作者：

Bendelac, A ^{[1
]}

机构：

[1] Univ Chicago, Comm Immunol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 06期

关键词：

D O I：

10.1038/ni0604-557

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Conventional wisdom holds that autoreactive thymocytes always undergo negative selection. This paradigm should be reassessed in light of evidence showing that alternative T cell lineages can develop in certain autoreactive conditions.

引用

页码：557 / 558

页数：2

共 13 条

[1] Origin of regulatory T cells with known specificity for antigen
Apostolou, I
Sarukhan, A
Klein, L
von Boehmer, H
[J]. NATURE IMMUNOLOGY, 2002, 3 (08) : 756 - 763
[2] Autoreactivity by design: Innate B and T lymphocytes
Bendelac, A
Bonneville, M
Kearney, JF
[J]. NATURE REVIEWS IMMUNOLOGY, 2001, 1 (03) : 177 - 186
[3] Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1T cells
Bendelac, A
Hunziker, RD
Lantz, O
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (04) : 1285 - 1293
[4] A thymic precursor to the NK T cell lineage
Benlagha, K
Kyin, T
Beavis, A
Teyton, L
Bendelac, A
[J]. SCIENCE, 2002, 296 (5567) : 553 - 555
[5] Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
Brigl, M
Bry, L
Kent, SC
Gumperz, JE
Brenner, MB
[J]. NATURE IMMUNOLOGY, 2003, 4 (12) : 1230 - 1237
[6] The dynamics of T cell receptor signaling: Complex orchestration and the key roles of tempo and cooperation
Germain, RN
Stefanova, I
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 467 - 522
[7] Regulation of cutaneous malignancy by γδ T cells
Girardi, M
Oppenheim, DE
Steele, CR
Lewis, JM
Glusac, E
Filler, R
Hobby, P
Sutton, B
Tigelaar, RE
Hayday, AC
[J]. SCIENCE, 2001, 294 (5542) : 605 - 609
[8] Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
Jordan, MS
Boesteanu, A
Reed, AJ
Petrone, AL
Holenbeck, AE
Lerman, MA
Naji, A
Caton, AJ
[J]. NATURE IMMUNOLOGY, 2001, 2 (04) : 301 - 306
[9] Precursors of functional MHC class I- or class II-restricted CD8αα+ T cells are positively selected in the thymus by agonist self-peptides
Leishman, AJ
Gapin, L
Capone, M
Palmer, E
MacDonald, HR
Kronenberg, M
Cheroutre, H
[J]. IMMUNITY, 2002, 16 (03) : 355 - 364
[10] T cell responses modulated through interaction between CD8αα and the nonclassical MHC class I molecule, TL
Leishman, AJ
Naidenko, OV
Attinger, A
Koning, F
Lena, CJ
Xiong, Y
Chang, HC
Reinherz, E
Kronenberg, M
Cheroutre, H
[J]. SCIENCE, 2001, 294 (5548) : 1936 - 1939

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