Stroke Risk of Blood Pressure Indices Determined by Home Blood Pressure Measurement The Ohasama Study

被引：28

作者：

Inoue, Ryusuke ^{[1
,2
]}

Ohkubo, Takayoshi ^{[1
,3
]}

Kikuya, Masahiro ^{[4
]}

Metoki, Hirohito ^{[4
]}

Asayama, Kei ^{[1
]}

Kanno, Atsuhiro ^{[4
]}

Obara, Taku ^{[4
]}

Hirose, Takuo ^{[4
]}

Hara, Azusa ^{[4
]}

Hoshi, Haruhisa ^{[5
]}

Totsune, Kazuhito ^{[1
,4
]}

Satoh, Hiroshi ^{[1
]}

Kondo, Yoshiaki ^{[1
,2
]}

Imai, Yutaka ^{[1
,4
]}

机构：

[1] Tohoku Univ, 21st Century COE Program, Comprehens Res & Educ Ctr Planning Drug Dev & Cli, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ, Dept Med Informat, Grad Sch Med, Sendai, Miyagi 9808574, Japan

[3] Tohoku Univ, Grad Sch Pharmaceut Sci & Med, Dept Planning Drug Dev & Clin Evaluat, Sendai, Miyagi 9808574, Japan

[4] Tohoku Univ, Grad Sch Pharmaceut Sci & Med, Dept Clin Pharmacol & Therapeut, Sendai, Miyagi 9808574, Japan

[5] Ohasama Hosp, Ohasama, Iwate, Japan

来源：

STROKE | 2009年 / 40卷 / 08期

基金：

日本学术振兴会;

关键词：

diastolic blood pressure; home blood pressure measurement; mean blood pressure; pulse pressure; stroke; systolic blood pressure; PULSE PRESSURE; MORTALITY; DISEASE; JAPAN;

D O I：

10.1161/STROKEAHA.108.546499

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-The purpose of this prospective cohort study was to investigate associations between stroke and blood pressure (BP) indices (systolic BP [SBP], diastolic BP [DBP], mean BP, and pulse pressure [ PP]) determined by home BP measurement. Methods-Associations between stroke and BP indices were examined in a rural Japanese population. Home BP data of 2369 subjects (40% men) >= 35 years of age (mean, 59 years) without a history of stroke were obtained. Associations between stroke and each index were determined using Cox proportional hazards regression and the likelihood ratio (LR)test. Results-During follow-up (mean, 11.7 years), 238 strokes occurred. The LR test showed that SBP and mean BP were significantly more strongly associated with total and ischemic stroke than DBP and PP (LR chi(2) >= 9.3, P < 0.01 for SBP/mean BP, LR chi(2) <= 3.8, P >= 0.05 for DBP/PP). SBP tended to be more strongly associated with total/ischemic stroke than mean BP (LR chi(2) = 3.8, P = 0.05 for SBP, LR chi(2) <= 0.2, P>0.6 for mean BP). PP tended to be slightly more strongly associated with ischemic stroke than DBP (LR chi(2) = 7.5, P<0.01 for DBP, LR chi(2)=9.3, P<0.01 for PP), whereas DBP was significantly more strongly associated with hemorrhagic stroke than PP (LR chi(2) = 9.2, P<0.01 for DBP, LR chi(2)=2.5, P=0.01 for PP). Conclusion-PP obtained from home BP measurements was weakly associated with stroke, whereas SBP showed the strongest association. Additionally, DBP and PP may be associated with different stroke types. (Stroke. 2009; 40: 2859-2861.)

引用

页码：2859 / 2861

页数：3

共 9 条

[1] Proposal of a Risk-Stratification System for the Japanese Population Based on Blood Pressure Levels: The Ohasama Study [J].