Microwave-assisted synthesis of 5-deaza-5,8-dihydropterins

被引：24

作者：

Bagley, MC ^{[1
]}

Singh, N ^{[1
]}

机构：

[1] Cardiff Univ, Dept Chem, Cardiff CF10 3TB, S Glam, Wales

来源：

SYNLETT | 2002年 / 10期

关键词：

dihydropyridopyrimidines; three-component cyclocondensations; microwave synthesis; heterocycles; Lewis acids;

D O I：

10.1055/s-2002-34246

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three-component cyclocondensation of 2,6-diaminopyrimidin-4-one, 1,3-dicarbonyl compounds or benzoylacetonitrile and aromatic or aliphatic aldehydes in the presence or absence of zinc(II) bromide proceeds under microwave-assisted conditions to give 5-deaza-5,8-dihydropterins in good yield and with total control of regiochemistry.

引用

页码：1718 / 1720

页数：3

共 21 条

[1] A new one-pot three-component condensation reaction for the synthesis of 5-deaza-5,8-dihydropterins
Bagley, MC
Singh, N
[J]. CHEMICAL COMMUNICATIONS, 2001, (23) : 2438 - 2439
[2] Bagley MC, 2001, SYNLETT, P1523
[3] A new and highly expedient synthesis of pyrido[2,3-d]pyrimidines
Bagley, MC
Hughes, DD
Lloyd, R
Powers, VEC
[J]. TETRAHEDRON LETTERS, 2001, 42 (37) : 6585 - 6588
[4] Synthesis and biological-activity of 7-Oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)
Borrell, JI
Teixidó, J
Matallana, JL
Martínez-Teipel, B
Colominas, C
Costa, M
Balcells, M
Schuler, E
Castillo, MJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (14) : 2366 - 2369
[5] ANTIMICROBIAL ACTIVITY OF 8-DEAZAFOLIC ACID
DEGRAW, JI
KISLIUK, RL
GAUMONT, Y
BAUGH, CM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (04) : 470 - 471
[6] SYNTHESIS AND ANTIFOLATE PROPERTIES OF 5,10-ETHANO-5,10-DIDEAZAAMINOPTERIN
DEGRAW, JI
CHRISTIE, PH
COLWELL, WT
SIROTNAK, FM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (02) : 320 - 324
[7] DEYANOV AB, 1991, KHIM FARM ZH+, V25, P26
[8] SYNTHESIS AND ANTI-TUMOR ACTIVITY OF 2,4-DIAMINO-6-(2,5-DIMETHOXYBENZYL)-5-METHYLPYRIDO[2,3-D]PYRIMIDINE
GRIVSKY, EM
LEE, S
SIGEL, CW
DUCH, DS
NICHOL, CA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (03) : 327 - 329
[9] Heckler R., 1991, European Patent, Patent No. [EP414386, 414386]
[10] Heckler R. E., 1991, CHEM ABSTR, V115, P71630

← 1 2 3 →