Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000

被引：41

作者：

Arai, H

Yamamoto, A

Matsuzawa, Y

Saito, Y

Yamada, N

Oikawa, S

Mabuchi, H

Teramoto, T

Sasaki, J

Nakaya, N

Itakura, H

Ishikawa, Y

Ouchi, Y

Horibe, H

Egashira, T

Hattori, H

Shirahashi, N

Kita, T

机构：

[1] Kyoto Univ, Sch Med, Dept Geriatr Med, Sakyo Ku, Kyoto 6068507, Japan

[2] Natl Cardiovasc Ctr, Osaka, Japan

[3] Osaka Univ, Dept Internal Med, Osaka, Japan

[4] Chiba Univ, Dept Internal Med, Chiba, Japan

[5] Univ Tsukuba, Dept Internal Med, Ibaraki, Japan

[6] Nippon Med Coll, Dept Internal Med, Tokyo, Japan

[7] Kanazawa Univ, Dept Internal Med, Kanazawa, Ishikawa, Japan

[8] Teikyo Univ, Dept Internal Med, Tokyo, Japan

[9] Int Univ Hlth & Welf, Tochigi, Japan

[10] Fussa Hosp, Tokyo, Japan

[11] Ibaraki Christian Univ, Ibaraki, Japan

[12] Kobe Univ, Fac Hlth Sci, Hyogo, Japan

[13] Univ Tokyo, Dept Geriatr Med, Tokyo, Japan

[14] Keisen Clin, Tokyo, Japan

[15] BML Inc, Dept Adv Technol & Dev, Tokyo, Japan

[16] Osaka City Univ, Sch Med, Osaka 545, Japan

[17] Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Kyoto, Japan

来源：

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | 2005年 / 12卷 / 05期

关键词：

hyperlipidemia; polymorphism; cholesterol ester transfer protein; lipoprotein lipase; triglyceride lipase; apolipoprotein CIII;

D O I：

10.5551/jat.12.240

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII (APOC3), and studied 2267 individuals randomly selected from the participants of Serum Lipid Survey 2000. There was a significant association of CETP polymorphism (D442G, lnt14 +1 G -> A, and TaqIB), LPL polymorphism (S447X), and LIPC polymorphism (-514 -> CT) with HDL-cholesterol levels. We also found a significant association of LPL polymorphism (S447X) and APOC3 polymorphism (Sstl) with triglyceride levels. This is the largest database showing the association of common genetic variants in lipid metabolism with serum lipid levels in the general Japanese population. Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events.

引用

页码：240 / 250

页数：11

共 54 条

[1] Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene [J].