Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma

被引：63

作者：

Forrest, Matthew S.

Skibola, Christine F. ^{[1
]}

Lightfoot, Tracy J.

Bracci, Paige M.

Willett, Eleanor V.

Smith, Martyn T.

Holly, Elizabeth A.

Roman, Eve

机构：

[1] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA

[2] Univ York, Dept Hlth Sci, Epidemiol & Genet Unit, York YO10 5DD, N Yorkshire, England

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2006年 / 134卷 / 02期

关键词：

lymphoma; infections; innate immunity; single nucleotide polymorphisms;

D O I：

10.1111/j.1365-2141.2006.06141.x

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Genetic variation in innate immunity may alter host-pathogen defence mechanisms and promote aberrant immune responses and non-Hodgkin lymphoma (NHL). To test this hypothesis, we investigated polymorphisms in innate immune genes in a pooled analysis of two population-based case-control studies of NHL from the San Francisco Bay Area (308 cases, 684 controls) and UK (596 cases, 758 controls). The caspase recruitment domain-containing protein 1007fs homozygote variant was positively associated with NHL risk (odds ratios (OR) = 3.1, 95% confidence intervals (CI) 1.1-8.8), whereas the toll-like receptor 4 1063A > G variant allele was inversely associated with diffuse large cell lymphoma (OR = 0.67, 95% CI 0.45-0.99). These results suggest that variation in innate immune genes may alter NHL susceptibility.

引用

页码：180 / 183

页数：4

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