How T cells use LFA-1 to attach and migrate

被引：58

作者：

Hogg, N ^{[1
]}

Smith, A ^{[1
]}

McDowall, A ^{[1
]}

Giles, K ^{[1
]}

Stanley, P ^{[1
]}

Laschinger, M ^{[1
]}

Henderson, R ^{[1
]}

机构：

[1] London Res Inst, Canc Res Uk, Leukocyte Adhes Lab, London WC2A 3PX, England

来源：

IMMUNOLOGY LETTERS | 2004年 / 92卷 / 1-2期

关键词：

T cell; integrin; adhesion; migration;

D O I：

10.1016/j.imlet.2003.10.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The T lymphocyte (or T cell) has classically been perceived to be a passive circular cell attaching to other cells or fibrils of the extracellular matrix when its integrins become activated. We now understand that the modus operandi of the T cell is migration. These cells are proving to be impressively fast migrators, clocking up basal speeds of similar to10-15 mum/min which makes them amongst the fastest movers recorded to date. Therefore, migration is the business of the T cell and in this review we will discuss how its motility is regulated and what functions this activity makes possible. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：51 / 54

页数：4

共 44 条

[1]

Activation of RhoA and ROCK are essential for detachment of migrating Leukocytes [J].

Alblas, J ;

Ulfman, L ;

Hordijk, P ;

Koenderman, L .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (07) :2137-2145

[2]

A role for Cdc42 in macrophage chemotaxis [J].

Allen, WE ;

Zicha, D ;

Ridley, AJ ;

Jones, GE .

JOURNAL OF CELL BIOLOGY, 1998, 141 (05) :1147-1157

[3]

A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow [J].

Alon, R ;

Aker, M ;

Feigelson, S ;

Sokolovsky-Eisenberg, M ;

Staunton, DE ;

Cinamon, G ;

Grabovsky, V ;

Shamri, R ;

Etzioni, A .

BLOOD, 2003, 101 (11) :4437-4445

[4]

Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse [J].

Ardouin, L ;

Bracke, M ;

Mathiot, A ;

Pagakis, SN ;

Norton, T ;

Hogg, N ;

Tybulewicz, VLJ .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (03) :790-797

[5]

Migration and T-lymphocyte effector function [J].

Bradley, LM .

CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (03) :343-348

[6]

The immunological synapse [J].

Bromley, SK ;

Burack, WR ;

Johnson, KG ;

Somersalo, K ;

Sims, TN ;

Sumen, C ;

Davis, MM ;

Shaw, AS ;

Allen, PM ;

Dustin, ML .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :375-396

[7]

Chemokines trigger immediate β2 integrin affinity and mobility changes:: Differential regulation and roles in lymphocyte arrest under flow [J].

Constantin, G ;

Majeed, M ;

Giagulli, C ;

Piccio, L ;

Kim, JY ;

Butcher, EC ;

Laudanna, C .

IMMUNITY, 2000, 13 (06) :759-769

[8]

Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes [J].

D'Souza-Schorey, C ;

Boettner, B ;

Van Aelst, L .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (07) :3936-3946

[9]

del Pozo MA, 1999, EUR J IMMUNOL, V29, P3609

[10]

CHEMOKINES REGULATE CELLULAR-POLARIZATION AND ADHESION RECEPTOR REDISTRIBUTION DURING LYMPHOCYTE INTERACTION WITH ENDOTHELIUM AND EXTRACELLULAR-MATRIX - INVOLVEMENT OF CAMP SIGNALING PATHWAY [J].

DELPOZO, MA ;

SANCHEZMATEOS, P ;

NIETO, M ;

SANCHEZMADRID, F .

JOURNAL OF CELL BIOLOGY, 1995, 131 (02) :495-508

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