The Platelet and Platelet Function Testing in Liver Disease

被引：50

作者：

Hugenholtz, Greg G. C. ^{[1
]}

Porte, Robert J. ^{[2
]}

Lisman, Ton ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Surg Res Lab, NL-9713 GZ Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Sect Hepatobiliary Surg & Liver Transplantat, NL-9713 GZ Groningen, Netherlands

来源：

CLINICS IN LIVER DISEASE | 2009年 / 13卷 / 01期

关键词：

Primary hemostasis; Platelets; Platelet function tests; Bleeding; Liver disease; VON-WILLEBRAND-FACTOR; DISSEMINATED INTRAVASCULAR COAGULATION; ARACHIDONIC-ACID METABOLISM; PROLONGED BLEEDING-TIME; RED-BLOOD-CELLS; CIRRHOTIC-PATIENTS; THROMBIN GENERATION; HEMOSTATIC ABNORMALITIES; ENDOTHELIAL DYSFUNCTION; FUNCTION ANALYZER;

D O I：

10.1016/j.cld.2008.09.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Patients who have liver disease commonly present with alterations in platelet number and function. Recent data have questioned the contribution of these changes to bleeding complications in these patients. Modern tests of platelet function revealed compensatory mechanisms for the decreased platelet number and function, the most prominent compensatory mechanism being substantially elevated levels of the adhesive protein von Willebrand's factor. Consequently, standard diagnostic tests of platelet functions seem to be of little use to predict bleeding complication in patients who have liver disease. This article outlines the role of platelet abnormalities and possibilities for platelet function testing in patients who have liver disease.

引用

页码：11 / +

页数：11

共 63 条

[1]

Von Willebrand factor could be an index of endothelial dysfunction in patients with cirrhosis:: relationship to degree of liver failure and nitric oxide levels [J].