Ustekinumab

被引:20
作者
Reich, Kristian [1 ]
Yasothan, Uma [2 ]
Kirkpatrick, Peter
机构
[1] Dermatologikum Hamburg, D-20354 Hamburg, Germany
[2] IMS Hlth, London NW1 6JB, England
关键词
INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; PLAQUE-TYPE PSORIASIS; QUALITY-OF-LIFE; DOUBLE-BLIND; SKIN; EFFICACY; SAFETY; TRIAL; METAANALYSIS; EXPRESSION;
D O I
10.1038/nrd2878
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 [微生物学]; 090105 [作物生产系统与生态工程];
摘要
In January 2009, ustekinumab (Stelara; Janssen Cilag) was granted marketing authorization by the European Commission for the treatment of moderate to severe plaque psoriasis in adults who failed to respond to, or who have a contraindication to, or are intolerant to other therapies including cyclosporine, methotrexate and phototherapy.
引用
收藏
页码:355 / 356
页数:2
相关论文
共 20 条
[1]
Disease severity, quality of life and health care in plaque-type psoriasis:: A multicenter cross-sectional study in Germany [J].
Augustin, M. ;
Krueger, K. ;
Radtke, M. A. ;
Schwippl, I. ;
Reich, K. .
DERMATOLOGY, 2008, 216 (04) :366-372
[2]
European patient perspectives on the impact of psoriasis:: the EUROPSO patient membership survey [J].
Dubertret, L. ;
Mrowietz, U. ;
Ranki, A. ;
van de Kerkhof, P. C. M. ;
Chimenti, S. ;
Lotti, T. ;
Schaefer, G. .
BRITISH JOURNAL OF DERMATOLOGY, 2006, 155 (04) :729-736
[3]
*EMEA, 2008, EUR PUBL ASS REP STE
[4]
Psoriasis: Emerging therapeutic strategies [J].
Gottlieb, AB .
NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (01) :19-34
[5]
Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial [J].
Gottlieb, Alice ;
Menter, Alan ;
Mendelsohn, Alan ;
Shen, Yaung-Kaung ;
Li, Shu ;
Guzzo, Cynthia ;
Fretzin, Scott ;
Kunynetz, Rod ;
Kavanaugh, Arthur .
LANCET, 2009, 373 (9664) :633-640
[6]
Hong K, 1999, J IMMUNOL, V162, P7480
[7]
A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis [J].
Kauffman, CL ;
Aria, N ;
Toichi, E ;
McCormick, TS ;
Cooper, KD ;
Gottlieb, AB ;
Everitt, DE ;
Frederick, B ;
Zhu, YW ;
Graham, MA ;
Pendley, CE ;
Mascelli, MA .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (06) :1037-1044
[8]
A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis [J].
Krueger, Gerald G. ;
Langley, Richard G. ;
Leonardi, Craig ;
Yeilding, Newman ;
Guzzo, Cynthia ;
Wang, Yuhua ;
Dooley, Lisa T. ;
Lebwohl, Mark .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (06) :580-592
[9]
Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris [J].
Lee, E ;
Trepicchio, WL ;
Oestreicher, JL ;
Pittman, D ;
Wang, F ;
Chamian, F ;
Dhodapkar, M ;
Krueger, JG .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (01) :125-130
[10]
Leonardi CL, 2008, LANCET, V371, P1665, DOI 10.1016/S0140-6736(08)60725-4