Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus

被引：21

作者：

Ichiishi, E

Yoshikawa, T

Kogawa, T

Yoshida, N

Kondo, M

机构：

[1] First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602, Kawaramachi-Hirokoji, Kamigyo-ku

来源：

GUT | 2000年 / 46卷 / 03期

关键词：

cancer; gastric; oesophageal; stomach; granulocyte colony stimulating factor; receptor;

D O I：

10.1136/gut.46.3.432

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Synchronous cancers of the oesophagus and stomach diagnosed in a patient showing pronounced leucocytosis were examined for production of granulocyte colony stimulating factor (G-CSF) and expression of G-CSF receptor. Whereas enzyme immunoassay of tissue extracts showed that the oesophageal carcinoma produced G-CSF, the gastric cancer did not. However, the gastric tumour showed G-CSF receptor expression on immunohistochemical examination of sections. These findings suggest that the oesophageal cancer promoted gastric cancer growth by paracrine mechanisms involving G-CSF.

引用

页码：432 / 434

页数：3

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