A high-sensitivity micromachined biosensor

被引：103

作者：

Baselt, DR ^{[1
]}

Lee, GU ^{[1
]}

Hansen, KM ^{[1
]}

Chrisey, LA ^{[1
]}

Colton, RJ ^{[1
]}

机构：

[1] GEOCENTERS INC, FT WASHINGTON, MD 20375 USA

来源：

PROCEEDINGS OF THE IEEE | 1997年 / 85卷 / 04期

关键词：

biomedical transducers; magnetic forces; magnetic materials; devices; magnetic transducers; microelectromechanical devices; piezoresistive materials;

D O I：

10.1109/5.573755

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The Force Amplified Biological Sensor (FABS) is a desktop or portable instrument currently under development at the Naval Research Laboratory. FABS will use a rapid automated immunoassay to detect analytes such as proteins, viruses, and bacteria. The assay uses forces produced by micron-sized magnetic particles to pull on antibody-antigen bonds. Microfabricated piezoresistive cantilevers measure the resulting piconewton-level forces with sufficient sensitivity to detect single antibody-antigen bonds. These forces also serve to characterize the bonds, allowing FABs to distinguish specific antibody-antigen bonds from nonspecific interactions.

引用

收藏

页码：672 / 680

页数：9

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