A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles

被引：36

作者：

Bilia, AR

Bergonzi, MC

Vincieri, FF

Lo Nostro, P

Morris, GA

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

[2] Univ Florence, Dept Pharmaceut Sci, I-50121 Florence, Italy

[3] Univ Florence, Dept Chem, I-50121 Florence, Italy

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2002年 / 91卷 / 10期

关键词：

DOSY; micelle(s); vitamin C; artemisinin; micellar solubilization;

D O I：

10.1002/jps.10217

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation. (C) 2002 Wiley-Liss, Inc.

引用

页码：2265 / 2270

页数：6

共 23 条

[1] ASSOCIATION OF BIOMOLECULAR SYSTEMS VIA PULSED-FIELD GRADIENT NMR SELF-DIFFUSION MEASUREMENTS [J].