A simple and regioselective carbon-oxygen bond cleavage using niobium(V)

被引：20

作者：

Arai, S ^{[1
]}

Sudo, Y ^{[1
]}

Nishida, A ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

SYNLETT | 2004年 / 06期

关键词：

dealkylation; Friedel-Crafts acylation; niobium;

D O I：

10.1055/s-2004-817766

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and convenient method for the differentiation of alkoxy groups on aromatic rings is described. Niobium(V) is found to possess a strong Lewis acid property to transform alkyl arylethers smoothly to the corresponding phenols in high yields. The excellent regioselectivity was also observed in dialkoxy benzene derivatives under mild conditions.

引用

页码：1104 / 1106

页数：3

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