Structural remodeling of resistance arteries in uremic hypertension

被引:20
作者
New, DI [1 ]
Chesser, AM [1 ]
Thuraisingham, RC [1 ]
Yaqoob, MM [1 ]
机构
[1] St Bartholomews Hosp, Anthony Raine Res Labs, London, England
关键词
uremia; hypertension; remodeling; elasticity; resistance artery;
D O I
10.1111/j.1523-1755.2004.00591.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background. Structural remodeling of the resistance vasculature is present in many forms of human and experimental hypertension. In particular, an increase in the ratio of wall thickness to lumen diameter develops, and might in itself maintain hypertension by increasing vascular resistance. Because uremia is associated with raised peripheral resistance, hypertension, and histologic changes suggestive of vascular remodeling, we sought to formally examine the structural and mechanical (elastic) properties of isolated pressurized resistance arteries in uremic hypertension. Methods. Cremaster, cerebral and mesenteric arteries from subtotally nephrectomised Wistar-Kyoto rats, normotensive control Wistar-Kyoto rats, and spontaneously hypertensive rats were mounted on a pressure myograph and relaxed in calcium-free buffer. Wall thickness and lumen diameter were measured at increasing lumen pressures from 10 to 200 mm Hg, and from this wall:lumen ratio. wall cross-sectional area, and an index of elasticity were derived. Results. In uremic hypertensive animals increased wall:lumen ratio and decreased lumen diameter was seen in cremaster and mesenteric arteries, although no significant changes were observed in cerebral arteries, compared to normotensive controls. In spontaneously hypertensive animals increased wall thickness and wall:lumen ratio was seen in cerebral and mesenteric arteries. decreased lumen diameter in cremaster and mesenteric arteries. and increased wall cross-sectional area in cerebral arteries. compared to normotensive controls. Elasticity of the arterial wall in uremic and spontaneously hypertensive animals did not differ from normotensive controls. Conclusion. Cremaster and mesenteric resistance arteries undergo predominantly eutrophic inward remodeling in uremic hypertension. broadly similar to that seen in spontaneous hypertension.
引用
收藏
页码:1818 / 1825
页数:8
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