Etiology of Adolescent Idiopathic Scoliosis: A Literature Review

被引：72

作者：

Kikanloo, Sina Rashidi ^{[1
]}

Tarpada, Sandip Parshottam ^{[1
]}

Cho, Woojin ^{[1
]}

机构：

[1] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Orthoped Surg, Bronx, NY 10467 USA

来源：

ASIAN SPINE JOURNAL | 2019年 / 13卷 / 03期

关键词：

Adolescent; Scoliosis; Adolescent idiopathic scoliosis; Etiology; Cobb angle; Review; SUSCEPTIBILITY GENE; PROGNOSTIC TEST; RARE VARIANTS; MELATONIN; ASSOCIATION; ETIOPATHOGENESIS; POLYMORPHISMS; PROGRESSION; EXPRESSION; RS4753426;

D O I：

10.31616/asj.2018.0096

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Adolescent idiopathic scoliosis (AIS) is the peripubertal development of spinal curvature of a minimum of 10 degrees. AIS is thought to be attributable to genetic factors, nutrition, early exposure to toxins, and hormonal dysregulation. Recent literature suggests these factors may compound to determine both disease onset and severity. Currently, treatment is limited to observation, bracing, and surgical intervention. Intervention is presently determined by severity and risk of curve progression. As they emerge, new therapies may target specific etiologies of AIS.

引用

页码：519 / 526

页数：8

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