Localization of transient receptor potential vanilloid (TRPV) in the human larynx

被引：44

作者：

Hamamoto, Takao ^{[1
]}

Takumida, Masaya ^{[1
]}

Hirakawa, Katsuhiro ^{[1
]}

Tatsukawa, Takaharu ^{[1
]}

Ishibashi, Takuya ^{[1
]}

机构：

[1] Hiroshima Univ, Dept Otorhinolaryngol Head & Neck Surg, Grad Sch Biomed Sci, Hiroshima, Japan

来源：

ACTA OTO-LARYNGOLOGICA | 2009年 / 129卷 / 05期

关键词：

TRPV; BDNF; larynx; epiglottis; human; immunohistochemistry; CHANNELS; NEUROPATHY; AFFERENT; CELLS; SKIN;

D O I：

10.1080/00016480802273108

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

Conclusion. Transient receptor potential vanilloid (TRPV) 1, 2, 3, and 4 were expressed in the human larynx, which may act as laryngeal nociceptors perceiving luminal noxious stimuli, play an important role in thermal sensation and osmotic sensation, and are also related to some pathological conditions and prevention of aspiration. Objective. Expression of TRPV1, 2, 3, and 4 in the human larynx was analyzed. Materials and methods. Specimens of human epiglottic epithelium obtained from six patients were used in this study. The localization of TRPV1, 2, 3, and 4 in the laryngeal epithelium was investigated by immunohistochemistry. Results. Immunohistochemical study revealed the presence of TRPV1, 2, 3, and 4 in the laryngeal epithelial cells. Chemoradiotherapy may reduce the expression of TRPV1, 2, 3, and 4, which might be a result of the mucositis and neuropathy in laryngeal epithelium.

引用

页码：560 / 568

页数：9

共 22 条

[1]

Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier [J].