An efficient Negishi cross-coupling reaction catalyzed by nickel(II) and diethyl phosphite

被引：54

作者：

Gavryushin, Andrei ^{[1
]}

Kofink, Christiane ^{[1
]}

Manolikakes, Georg ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

TETRAHEDRON | 2006年 / 62卷 / 32期

关键词：

D O I：

10.1016/j.tet.2006.03.123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A combination of diethyl phosphite-DMAP and Ni(II) salts forms a very effective catalytic system for the cross-coupling reactions of arylzinc halides with aryl, heteroaryl, and alkenyl bromides. chlorides. triflates. and nonaflates. The choice of solvent is quite important and the mixture of THF-N-ethylpyrrolidinone (NEP) (8: 1) was found to be optimal. The reaction usually requires only 0.05 moll % of NiCl2 or Ni(acac)(2) as catalyst and proceeds at room temperature within 1-48 h. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7521 / 7533

页数：13

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