The transcriptional coactivators p300 and CBP are histone acetyltransferases

被引：2414

作者：

Ogryzko, VV

Schiltz, RL

Russanova, V

Howard, BH

Nakatani, Y

机构：

[1] Lab. of Molecular Growth Regulation, Natl. Inst. of Child Hlth./Hum. D., National Institutes of Health, Bethesda

来源：

CELL | 1996年 / 87卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(00)82001-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the cellular p300/CBP associated factor (PCAF), possesses intrinsic histone acetyltransferase activity. Here, we demonstrate that p300/CBP is not only a transcriptional adaptor but also a histone acetyltransferase. p300/CBP represents a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyltransferases. p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF.

引用

页码：953 / 959

页数：7

共 42 条

[1] ABRAHAM SE, 1993, ONCOGENE, V8, P1639
[2] ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
[3] A FAMILY OF TRANSCRIPTIONAL ADAPTER PROTEINS TARGETED BY THE E1A ONCOPROTEIN
ARANY, Z
NEWSOME, D
OLDREAD, E
LIVINGSTON, DM
ECKNER, R
[J]. NATURE, 1995, 374 (6517) : 81 - 84
[4] E1A-ASSOCIATED P300 AND CREB-ASSOCIATED CBP BELONG TO A CONSERVED FAMILY OF COACTIVATORS
ARANY, Z
SELLERS, WR
LIVINGSTON, DM
ECKNER, R
[J]. CELL, 1994, 77 (06) : 799 - 800
[5] TOPOGRAPHY OF THE HISTONE OCTAMER SURFACE - REPEATING STRUCTURAL MOTIFS UTILIZED IN THE DOCKING OF NUCLEOSOMAL DNA
ARENTS, G
MOUDRIANAKIS, EN
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (22) : 10489 - 10493
[6] ACTIVATION OF CAMP AND MITOGEN RESPONSIVE GENES RELIES ON A COMMON NUCLEAR FACTOR
ARIAS, J
ALBERTS, AS
BRINDLE, P
CLARET, FX
SMEAL, T
KARIN, M
FERAMISCO, J
MONTMINY, M
[J]. NATURE, 1994, 370 (6486) : 226 - 229
[7] Bannister AJ, 1995, ONCOGENE, V11, P2509
[8] The translocation t(8;l6)(p11, p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB binding protein
Borrow, J
Stanton, VP
Andresen, JM
Becher, R
Behm, FG
Chaganti, RSK
Civin, CI
Disteche, C
Dube, I
Frischauf, AM
Horsman, D
Mitelman, F
Volinia, S
Watmore, AE
Housman, DE
[J]. NATURE GENETICS, 1996, 14 (01) : 33 - 41
[9] Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation
Brownell, JE
Zhou, JX
Ranalli, T
Kobayashi, R
Edmondson, DG
Roth, SY
Allis, CD
[J]. CELL, 1996, 84 (06) : 843 - 851
[10] Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation
Brownell, JE
Allis, CD
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (02) : 176 - 184

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