Effects of radiation on a model of malignant glioma invasion

被引：24

作者：

Bauman, GS

MacDonald, W

Moore, E

Ramsey, DA

Fisher, BJ

Amberger, VR

Del Maestro, RM

机构：

[1] London Reg Canc Clin, Dept Radiat Oncol, London, ON N6C 1T5, Canada

[2] Univ Western Ontario, Dept Oncol, London, ON N6A 3K7, Canada

[3] London Hlth Sci Ctr, Div Neurosurg, Expt Res Unit, Brain Res Lab, London, ON, Canada

[4] London Hlth Sci Ctr, Dept Pathol, London, ON, Canada

[5] Univ Western Ontario, Dept Clin Neurol Sci, Div Neurosurg, London, ON N6A 3K7, Canada

[6] London Hlth Sci Ctr, Brain Tumor Tissue Bank, London, ON, Canada

来源：

JOURNAL OF NEURO-ONCOLOGY | 1999年 / 44卷 / 03期

关键词：

glioma; invasion; radiation;

D O I：

10.1023/A:1006319417077

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We sought to characterize the effects of radiation alone and in combination with BCNU and dexamethasone on malignant glioma invasion. A model of malignant glioma invasion into a gel matrix of collagen type I was used to characterize response to radiation treatment for four malignant glioma cell lines (C6, U251, U373, A172) and nine primary human glioblastoma explants. A radiation dose dependent inhibition of invasion was noted for the C6 astrocytoma cell line but not the other cell lines or explants. Addition of BCNU and dexamethasone to radiation produced additional inhibition of invasion among the cell lines and explants but could not suppress invasion entirely.

引用

页码：223 / 231

页数：9

共 27 条

[1] Bihemispheric malignant glioma: One size does not fit all [J].