α-Amylase inhibitory effect of 3β-olean-12-en-3-yl (9Z)-hexadec-9-enoate isolated from Spondias mombin leaf

被引：54

作者：

Fred-Jaiyesimi, Adediwura ^{[1
]}

Kio, Abo ^{[2
]}

Richard, Wilkins ^{[1
]}

机构：

[1] Newcastle Univ, Sch Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Univ Ibadan, Fac Pharm, Ibadan, Nigeria

来源：

FOOD CHEMISTRY | 2009年 / 116卷 / 01期

关键词：

Spondias mombin; alpha-Amylase inhibitor; Diabetes; PLANT ANTIVIRAL AGENTS; GLUCOSIDASE INHIBITION; ESTERS; BETA;

D O I：

10.1016/j.foodchem.2009.02.047

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Spondias mombin is a traditional herb used in the treatment of diabetes mellitus by traditional healers in southwest Nigeria. In this study. we investigated the antidiabetic activity using alpha-amylase inhibitory assay and isolated an active Compound. The bioactivity assay-guided study demonstrated the presence of an alpha-amylase inhibitory fraction from S. mombin leaf. An active compound, 3 beta-olean-12-en-3-yl (9Z)-hexadec-9-enoate was also studied. This is reported, from this plant, for the first time. The methanol extract, diethyl ether fraction and the isolated Compound exhibited significant enzyme inhibitory activity against Aspergillus oryzae alpha-amylase. Our study revealed, for the first time, the isolation and alpha-amylase inhibitory activity of 3 beta-olean-12-en-3-yl (9Z)-hexadec-9-enoate from S. mombin leaf. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：285 / 288

页数：4

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