Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction

被引:958
作者
Chen, SL [1 ]
Fang, W
Ye, F
Liu, YH
Qian, J
Shan, S
Zhang, J
Zhao, RCH
Liao, LM
Lin, S
Sun, JP
机构
[1] Nanjing Univ, Div Cardiol, Nanjing Hosp 1, Nanjing 210006, Jiangsu, Peoples R China
[2] China United Med Univ, Bone Marrow Stem Cell Ctr, Beijing, Peoples R China
[3] Maanshan peoples Hosp, Dept Cardiol, Maanshan, Anhui, Peoples R China
[4] Cleveland Clin Fdn, Cleveland, OH 44195 USA
关键词
D O I
10.1016/j.amjcard.2004.03.034
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sixty-nine patients who underwent primary percutaneous coronary intervention within 12 hours after onset of acute myocardial infarction were randomized to receive intracoronary injection of autologous bone marrow mesenchymal stem cell or standard saline. Several imagining techniques demonstrated that bone marrow mesenchymal stem cells significantly improved left ventricular function. (C) 2004 by Excerpta Medical, Inc.
引用
收藏
页码:92 / 95
页数:4
相关论文
共 14 条
  • [1] The evolving concept of a stem cell: Entity or function?
    Blau, HM
    Brazelton, TR
    Weimann, JM
    [J]. CELL, 2001, 105 (07) : 829 - 841
  • [2] EMERSON CP, 2003, CIRCULATION, V107, P935
  • [3] Development of regenerative cardiomyocytes from mesenchymal stem cells for cardiovascular tissue engineering
    Fukuda, K
    [J]. ARTIFICIAL ORGANS, 2001, 25 (03) : 187 - 193
  • [4] Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase
    Jaiswal, RK
    Jaiswal, N
    Bruder, SP
    Mbalaviele, G
    Marshak, DR
    Pittenger, MF
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (13) : 9645 - 9652
  • [5] In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
    Johnstone, B
    Hering, TM
    Caplan, AI
    Goldberg, VM
    Yoo, JU
    [J]. EXPERIMENTAL CELL RESEARCH, 1998, 238 (01) : 265 - 272
  • [6] Leor J, 1996, CIRCULATION, V94, P332
  • [7] Skeletal myoblast transplantation for repair of myocardial necrosis
    Murry, CE
    Wiseman, RW
    Schwartz, SM
    Hauschka, SD
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (11) : 2512 - 2523
  • [8] VENTRICULAR REMODELING AFTER MYOCARDIAL-INFARCTION - EXPERIMENTAL-OBSERVATIONS AND CLINICAL IMPLICATIONS
    PFEFFER, MA
    BRAUNWALD, E
    [J]. CIRCULATION, 1990, 81 (04) : 1161 - 1172
  • [9] Electromechanical mapping for detecting myocardial viability and ischemia in patients with severe ischemic cardiomyopathy
    Samady, H
    Liu, YH
    Choi, CJ
    Ragosta, M
    Pfau, SE
    Cleman, MW
    Powers, ER
    Kramer, CM
    Wackers, FJT
    Beller, GA
    Watson, DD
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2003, 91 (07) : 807 - 811
  • [10] Quantitative gated single photon emission computed tomography imaging: A counts-based method for display and measurement of regional and global ventricular systolic function
    Smith, WH
    Kastner, RJ
    Calnon, DA
    Segalla, D
    Beller, GA
    Watson, DD
    [J]. JOURNAL OF NUCLEAR CARDIOLOGY, 1997, 4 (06) : 451 - 463