ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas

被引：21

作者：

Burim, Regislaine Valeria ^{[1
,2
]}

Teixeira, Silvia Aparecida ^{[2
]}

Colli, Benedicto Oscar ^{[2
]}

Peria, Fernanda Maris ^{[3
]}

Tirapelli, Luis Fernando ^{[2
]}

Nagahashi Marie, Suely Kazue ^{[4
]}

Fleury Malheiros, Suzana Maria ^{[5
]}

Oba-Shinjo, Sueli Mieko ^{[6
]}

Gabbai, Alberto Alain ^{[5
]}

Lotufo, Paulo Andrade ^{[7
]}

Carlotti-Junior, Carlos Gilberto ^{[2
]}

机构：

[1] Univ Sao Paulo, FCFRP, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, BR-14040903 Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Surg & Anat, BR-14040903 Ribeirao Preto, SP, Brazil

[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Internal Med, BR-14040903 Ribeirao Preto, SP, Brazil

[4] Univ Sao Paulo, Fac Med, Dept Neurol, Sao Paulo, Brazil

[5] Univ Fed Sao Paulo, Fac Med, Dept Neurol, Sao Paulo, Brazil

[6] Univ Sao Paulo, Fac Med, Dept Internal Med, Sao Paulo, Brazil

[7] Univ Sao Paulo, Sao Paulo Univ Hosp, Sao Paulo, Brazil

来源：

CLINICAL AND EXPERIMENTAL MEDICINE | 2009年 / 9卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Astrocytoma; Polymorphism; PECAM-1; ICAM-1; INTERCELLULAR-ADHESION MOLECULE-1; ACUTE MYOCARDIAL-INFARCTION; INFLAMMATORY-BOWEL-DISEASE; VERSUS-HOST-DISEASE; GENE POLYMORPHISMS; MULTIPLE-SCLEROSIS; JAPANESE POPULATION; BEHCETS-DISEASE; CELL MIGRATION; SOLUBLE LEVEL;

D O I：

10.1007/s10238-009-0040-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) play an important role in glioma invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and PECAM-1 could be associated with glioma development and progression. Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis. The distribution of PECAM-1 polymorphic genotypes in astrocytomas did not show any significant difference. However, a specific ICAM-1 genotype (G/G, corresponding to Lys469Glu) exhibited higher frequency in grade II astrocytomas compared to controls, grade III, and grade IV astrocytomas; suggesting that this polymorphism could be involved in the development of grade II astrocytomas.

引用

页码：157 / 163

页数：7

共 59 条

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